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ATP modulation of large conductance Ca2+-activated K+ channels via a functionally associated protein kinase A in CA1 pyramidal neurons from rat hippocampus

โœ Scribed by Liang W Gong; Tian M Gao; Hao Huang; Ke-Xiong Zhou; Zhenqing Tong


Book ID
113998409
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
271 KB
Volume
951
Category
Article
ISSN
0006-8993

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## Abstract The effects of rottlerin, a known inhibitor of protein kinase Cโ€ฮด activation, on ion currents were investigated in pituitary tumor (GH~3~) cells. Rottlerin (0.3โ€“100 ยตM) increased the amplitude of Ca^2+^โ€activated K^+^ current (I~K(Ca)~) in a concentrationโ€dependent manner with an EC~50~