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ATP-induced apoptosis involves a Ca2+-independent phospholipase A2 and 5-lipoxygenase in macrophages

✍ Scribed by Helio Miranda Costa-Junior; Anderson Nogueira Mendes; Gustavo Henrique Nolasco Grimmer Davis; Cristiane Monteiro da Cruz; Ana Lúcia Marques Ventura; Carlos Henrique Serezani; Lucia Helena Faccioli; Auro Nomizo; Célio G. Freire-de-Lima; Rodrigo da Cunha Bisaggio; Pedro Muanis Persechini

Book ID
113865106
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
1021 KB
Volume
88
Category
Article
ISSN
0090-6980

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Phospholipase A2-independent Ca2+ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells
✍ Sau-Tung Chu; He-Hsiung Cheng; Chun-Jen Huang; Hong-Chiang Chang; Chao-Chuan Chi 📂 Article 📅 2007 🏛 Elsevier Science 🌐 English ⚖ 363 KB

Melittin, a peptide from bee venom, is thought to be a phospholipase A(2) activator and Ca(2+) influx inducer that can evoke cell death in different cell types. However, the effect of melittin on cytosolic free Ca(2+) concentration ([Ca(2+)](i)) and viability has not been explored in human osteoblas