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Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR

✍ Scribed by Fawzi, Nicolas L.; Ying, Jinfa; Ghirlando, Rodolfo; Torchia, Dennis A.; Clore, G. Marius


Book ID
124079822
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
381 KB
Volume
480
Category
Article
ISSN
0028-0836

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## Abstract The structure and aggregation state of amyloid β‐peptide (A__β__) in membrane‐like environments are important determinants of pathological events in Alzheimer’s disease. In fact, the neurotoxic nature of amyloid‐forming peptides and proteins is associated with specific conformational tr