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Atomic Level Description of GPCR Activation Revealed by Microsecond Time Scale Molecular Dynamics

โœ Scribed by Lynch, Diane; Hurst, Dow; Reggio, Patti; Grossfield, Alan; Pitman, Mike


Book ID
122191308
Publisher
Biophysical Society
Year
2009
Tongue
English
Weight
36 KB
Volume
96
Category
Article
ISSN
0006-3495

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## Abstract ## BACKGROUND: The tyrosine kinase Janus kinase 2 (JAK2) is important in triggering nuclear translocation and regulation of target genes expression through signal transducer and activator of transcription pathways. The valineโ€toโ€phenylalanine mutation at amino acid 617 (V617F), which r