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Atomic charges derived from semiempirical methods

✍ Scribed by Brent H. Besler; Kenneth M. Merz Jr.; Peter A. Kollman

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 788 KB
Volume: 11
Category: Article
ISSN: 0192-8651
DOI: 10.1002/jcc.540110404

No coin nor oath required. For personal study only.

✦ Synopsis

It is demonstrated that semiempirical methods give electrostatic potential (ESP) derived atomic point charges that are in reasonable agreement with ab initio ESP charges. Furthermore, we find that MNDO ESP charges are superior to AM1 ESP charges in correlating with ESP charges derived from the 6-31G" basis set. Thus, it is possible to obtain 6-31G" quality point charges by simply scaling MNDO ESP charges. The charges are scaled in a linear ( y = Mrc) manner to conserve charge. In this way researchers desiring to carry out force field simulations or minimizations can obtain charges by using MNDO, which requires much less computer time than the corresponding 6-31G" calculation.

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