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Atom Transfer Radical Polymerization with Polypeptide Initiators: A General Approach to Block Copolymers of Sequence-Defined Polypeptides and Synthetic Polymers

✍ Scribed by Hartmut Rettig; Eberhard Krause; Hans G. Börner

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
180 KB
Volume
25
Category
Article
ISSN
1022-1336

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✦ Synopsis

Abstract

Summary: A novel two‐step polymerization strategy allowing the integration of sequence‐defined oligopeptides into synthetic polymers has been demonstrated by the successful synthesis of an oligopeptide‐block‐poly(n‐butyl acrylate) copolymer. The approach utilizes a solid‐phase supported synthesis of an oligopeptide macroinitiator (SPPS) followed by solution‐phase atom transfer radical polymerization (ATRP) initiated by the oligopeptide macroinitiator. The resulting block copolymer exhibited a low $\overline M _{\rm w} /\overline M _{\rm n}$ (1.19) and a controllable $\overline M _{\rm n}$.

Poly(n‐butyl acrylate)‐block‐oligopeptide.

imagePoly(n‐butyl acrylate)‐block‐oligopeptide.

📜 SIMILAR VOLUMES

Poly(N-hydroxyethylacrylamide) Prepared
Poly(N-hydroxyethylacrylamide) Prepared by Atom Transfer Radical Polymerization as a Nonionic, Water-Soluble, and Hydrolysis-Resistant Polymer and/or Segment of Block Copolymer with a Well-Defined Molecular Weight
✍ Atsushi Narumi; Yougen Chen; Masako Sone; Keita Fuchise; Ryosuke Sakai; Toshifum 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 268 KB

## Abstract __N__‐Hydroxyethylacrylamide (HEAA) was polymerized using the atom transfer radical polymerization (ATRP) with ethyl 2‐chloropropionate (ECP), copper(I) chloride (CuCl), and tris[2‐(dimethylamino)ethyl]amine (Me~6~TREN) in ethanol/water, producing poly(__N__‐hydroxyethylacrylamide) (PHE