𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Atmospheric pressure ion mobility spectrometry of protonated and sodiated peptides

✍ Scribed by Ching Wu; Jörg Klasmeier; Herbert H. Hill; Jr.

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
71 KB
Volume
13
Category
Article
ISSN
0951-4198

No coin nor oath required. For personal study only.

✦ Synopsis

A number of peptides were studied with electrospray ionization -ion mobility spectrometry/mass spectrometry (ESI-IMS/MS). The ion mobility data were used to calculate the average collision cross sections of the different detected peptide ions in the nitrogen drift gas. By comparing the cross sections of related ions, structural information about the most probable location of the charge and the gas-phase ion conformations was deduced. For bradykinin and kemptide, a significant mobility difference between protonated and sodiated species (where sodium replaced a proton in singly and doubly charged peptides) was demonstrated. Surprisingly, the doubly charged sodiated peptides had a smaller collision cross section than the doubly charged protonated ones leading to the conclusion that the gas-phase conformations of these ions are different with respect to intramolecular interactions.

📜 SIMILAR VOLUMES

Confirmation of avermectin residues in f
Confirmation of avermectin residues in food matrices with negative-ion atmospheric pressure chemical ionization liquid chromatography/mass spectrometry
✍ Sherri B. Turnipseed; José E. Roybal; Heidi S. Rupp; Steve A. Gonzales; Allen P. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB 👁 2 views

A multi-residue LC/MS method has been developed to confirm avermectin drug residues in several food matrices. Ivermectin (IVR), doramectin (DOR), eprinomectin (EPR) and moxidectin (MOX) are confirmed using atmospheric pressure chemical ionization (APCI) with negative ion detection and selected ion m

Determination of LY355703 in dog and mou
Determination of LY355703 in dog and mouse plasma by positive ion liquid chromatography/tandem mass spectrometry with atmospheric pressure chemical ionization
✍ Berna, M.; Shugert, R.; Mullen, J. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 268 KB 👁 1 views

A liquid chromatographic/mass spectrometric assay was developed for the determination of LY355703, a potent anti-tumor drug, in mouse and dog plasma. Empore (3M) solid-phase extraction cartridges were used for C 18 sample preparation in conjunction with a positive pressure manifold. Chromatographic

Structural Effects on the Formation of P
Structural Effects on the Formation of Proton and Alkali Metal Ion Adducts of Apolar, Neutral Peptides: Electrospray Ionization Mass Spectrometry and Ab Initio Theoretical Studies
✍ R. Sudha; M. Panda; J. Chandrasekhar; Padmanabhan Balaram 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 314 KB 👁 2 views

Apolar, neutral peptides have been shown to ionize extremely well under the conditions used for electrospray ionization mass spectrometry (ESIMS). Peptides for which the conformations have been independently determined in solution and in crystals have been examined by ESIMS. Studies of peptide helic