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ATM heterozygosity in breast cancer patients predicts for an increase in radiation-induced late effects

✍ Scribed by C.M. Iannuzzi; D.P. Atencio; S. Green; R.G. Stock; B.S. Rosenstein


Book ID
108434507
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
16 KB
Volume
51
Category
Article
ISSN
0360-3016

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We observed severe late effects in a patient treated with radiation therapy for breast cancer. Radiation survival studies of patient fibroblasts show an enhanced cellular radiation sensitivity (Do = 0.95 Gy). Genetic analysis reveals that the patient is heterozygous for a mutated ATM gene. Protein t