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ATM haplotypes and breast cancer risk in Jewish high-risk women

✍ Scribed by Koren, M; Kimmel, G; Ben-Asher, E; Gal, I; Papa, M Z; Beckmann, J S; Lancet, D; Shamir, R; Friedman, E

Book ID: 121840147
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 107 KB
Volume: 94
Category: Article
ISSN: 0007-0920
DOI: 10.1038/sj.bjc.6603062

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The ATM gene is mutated in ataxia-telangiectasia (AT). Heterozygote female relatives of AT cases have a 2-7fold increased risk of breast cancer. We previously reported high risks of breast cancer associated with certain ATM variants. To estimate the risks more precisely, we have examined two ATM var