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ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation

✍ Scribed by Ababou, Mouna; Dutertre, Stéphanie; Lécluse, Yann; Onclercq, Rosine; Chatton, Bruno; Amor-Guéret, Mounira


Book ID
110064313
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
227 KB
Volume
19
Category
Article
ISSN
0950-9232

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DEAE-cellulose chromatography of the 20,000g supernatant fraction of homogenates of C-1300 murine neuroblastoma (clone N2a) yields one major and two minor peaks of cyclic AMP-dependent protein kinase activity. Assessment of the endogenous activation state of the enzyme(s) reveals that the enzyme is