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ATM and the DNA damage response

✍ Scribed by Lavin, Martin F; Delia, Domenico; Chessa, Luciana

Book ID
110032978
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
188 KB
Volume
7
Category
Article
ISSN
1469-221X

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## Abstract After irradiation, ATM defective cells accumulate unrepaired double strand breaks (DSBs) for several cell divisions. At the chromosome level, unresolved DSBs appear as chromosome breaks that can be efficiently scored by using telomeric and mFISH probes. H2AX is immediately activated by

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