Atherosclerosis: Molecular and Cellular Mechanisms

• Publisher: Wiley-Blackwell
• Year: 2010
• Tongue: English
• Leaves: 405
• Category: Library

✦ Synopsis

With atherosclerosis being the number one cause of death in the western world, this handbook and ready reference provides a comprehensive account of the different stages and factors in the development of the atherosclerotic plaque.
Each chapter is written by experts in the field and highlights the role of specific mediators of atherosclerotic plaque development, as well as potential therapeutic targets. A large amount of this up-to-date information is conveyed by way of tables and schematic figures, in a readily comprehensible manner.
A must-have for master and PhD students, researchers, MDs and lecturers in vascular biology and cardiology, as well as for academics and scientists in the pharmaceutical industry.

✦ Table of Contents

Content:
Chapter 1 Pathogenesis of Atherosclerosis (pages 1–20): Dr. Sarah Jane George and Cressida Lyon
Chapter 2 Chemokines and Atherosclerosis: A Critical Assessment of Therapeutic Targets (pages 21–42): Gemma E. White, Keith M. Channon and David R. Greaves
Chapter 3 Adhesion Molecules and Atherosclerosis (pages 43–62): Huan Wang and Yuqing Huo
Chapter 4 Cytokines and Atherosclerosis (pages 63–84): Alain Tedgui, Hafid Ait?Oufella and Ziad Mallat
Chapter 5 Toll?Like Receptors in Atherosclerosis (pages 85–103): Zhong?Qun Yan, Kristina Edfeldt and Anna M. Lundberg
Chapter 6 PPAR?Based Therapies for the Management of Atherosclerosis (pages 105–135): Florence Gizard and Ines Pineda?Torra
Chapter 7 Pentraxins in Vascular Pathology: The Role of PTX3 (pages 137–154): Alberto Mantovani, Cecilia Garlanda, Barbara Bottazzi, Fabiola Molla and Roberto Latini
Chapter 8 Metalloproteinases, the Endothelium, and Atherosclerosis (pages 155–172): Stephen J. White and Andrew C. Newby
Chapter 9 Cathepsins in Atherosclerosis (pages 173–191): Lili Bai, Esther Lutgens and Sylvia Heeneman
Chapter 10 The Plasmin System and Atherosclerosis (pages 193–206): Christopher L. Jackson and Kevin G. S. Carson
Chapter 11 Mast Cell Proteases and Atherosclerosis (pages 207–228): Petri T. Kovanen
Chapter 12 Macrophage Foam Cell Formation: The Pathways to Cholesterol Engorgement (pages 229–254): Kathryn J. Moore and Katey Rayner
Chapter 13 NADPH Oxidase and Atherosclerosis (pages 255–273): Jamie Y. Jeremy, Saima Muzaffar, Carina Mill and Nilima Shukla
Chapter 14 Uncoupling of Endothelial Nitric Oxide Synthase in Atherosclerosis (pages 275–299): Colin Cunnington and Keith M. Channon
Chapter 15 Heme Oxygenase?1 and Atherosclerosis (pages 301–323): Justin C. Mason and Faisal Ali
Chapter 16 Phenotypic Heterogeneity of Smooth Muscle Cells – Implications for Atherosclerosis (pages 325–342): Matteo Coen and Marie?Luce Bochaton?Piallat
Chapter 17 Platelets: Their Role in Atherogenesis and Thrombosis in Coronary Artery Disease (pages 343–363): Matthew T. Harper, Lucy MacCarthy?Morrogh, Matthew L. Jones, Olga Konopatskaya and Alastair W. Poole
Chapter 18 Modulators of Monocyte and Macrophage Phenotypes in Atherosclerosis (pages 365–386): Jason L. Johnson and Nicholas P. Jenkins