## Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement and cancer predisposition, caused by mutations in the A-T mutated (ATM) gene. To study genotypephenotype correlations, we evaluated the clinical and laboratory data of 51 genetically prov
✦ LIBER ✦
Ataxia-Telangiectasia: Phenotype/Genotype Studies of ATM Protein Expression, Mutations, and Radiosensitivity
✍ Scribed by Sara G. Becker-Catania; Gang Chen; Mee Jeong Hwang; Zhijun Wang; Xia Sun; Ozden Sanal; Eva Bernatowska-Matuszkiewicz; Luciana Chessa; Eva Y.-H.P. Lee; Richard A. Gatti
- Book ID
- 115639680
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 183 KB
- Volume
- 70
- Category
- Article
- ISSN
- 1096-7192
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## Abstract ## BACKGROUND. The double‐strand break (DSB) repair capacity has been implicated in the survival of patients in several cancer types. However, little is known about the prognostic importance of the key DSB repair genes—ataxia‐telangiectasia mutated (__ATM__), DNA‐dependent protein kina