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Ataxia telangiectasia and acinic cell carcinoma of the parotid gland

✍ Scribed by Charles Mock; George Coleman; John H. Ree; Dianne N. Abuelo; James P. Crowley

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 730 KB
Volume: 39
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930390214

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✦ Synopsis

An increased incidence of malignancies occurs in ataxia telangiectasia.These are most frequently hematopoietic in children and epithelial in adults. Both cellular immunodeficiency and chromosome damage have been implicated in their etiology. There has been only one report of a salivary malignancy, a parotid mucoepidermoid carcinoma. We describe a second salivary malignancy, a metastasizing acinic cell carcinoma of the parotid gland, that developed in a 33-yr-old woman with ataxia telangiectasia. The marked chromosomal abnormalities that were present may have been involved in the pathogenesis of her tumor.

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