𝔖 Bobbio Scriptorium
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A/T-targeted somatic hypermutation: critique of the mainstream model

✍ Scribed by Andrew Franklin; Robert V. Blanden

Book ID
113931279
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
316 KB
Volume
31
Category
Article
ISSN
0968-0004

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Recruitment of somatic hypermutation to the Ig kappa locus has previously been shown to depend on the enhancer elements, Ei/MAR and E3'. Here we show that these elements are not sufficient to confer mutability. However, hypermutation is effectively targeted to a chimeric beta-globin/Ig kappa transge