Asymptotic distributions of polylocus test statistics

✍ Scribed by Darlene R. Goldstein

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 457 KB
• Volume: 12
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.1370120207

✦ Synopsis

Polylocus linkage analysis methods are modified two-point analyses which aim to approach the information gain of multilocus analysis. Terwilliger and Ott [( 1992) Am JHum Genet 5 1 :A202, (1993) Genet Epidemiol10:477-482] put forth two such methods. This paper presents asymptotic approximations to the null distribution of the likelihood ratio statistics for these two methods, correcting earlier reports [Terwilliger and Ott ( 1 993) Genet Epiderniol10:477-482; Schaid and Elston (1994) Genet Epidemiol 1 1: 1-17]. The performance of the approximations is then assessed for finite samples of fully informative meioses.