✦ LIBER ✦

Asymptomatic spontaneous cerebral emboli and cognitive decline in a cohort of older people: a prospective study

✍ Scribed by Richard C. Oude Voshaar; Nitin Purandare; Jayne Hardicre; Charles McCollum; Alistair Burns

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 102 KB
Volume: 22
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.1744

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Asymptomatic spontaneous cerebral emboli (SCE) are common in dementia and are associated with cognitive decline in dementia. The significance of their presence in older people is unknown.

Method

We included 96 participants (mean (SD) age 76.8 (6.7) years, 46% female) who were the control group in a case‐control study to evaluate SCE in dementia. Cognitive functioning was assessed prospectively over 2.5 years, using the MMSE and CAMCOG.

Results

The mean (SD) MMSE score was 28.7 (1.4) at baseline with an average (SD) drop of 0.79 (0.91) per year. The presence of SCE was not related to the annual drop in MMSE score, nor to the CAMCOG score at follow‐up (p = 0.88 and p = 0.41, respectively). Linear regression analyses identified higher age in years (β = 0.29, p = 0.003), history of stroke (β = 0.31, p = 0.001) and carotid stenosis (β = 0.28, p = 0.003) as independent predictors of cognitive decline.

Conclusion

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