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Asymmetrical nitrogen. 51. Synthesis and optical activation of 1,6-diazabicyclo-[3.1.0]hexane-5-carboxylic acid and its derivatives

โœ Scribed by G. V. Shustov; S. N. Denisenko; A. B. Zolotoi; O. A. D'yachenko; L. O. Atovmyan; R. G. Kostyanovskii


Book ID
112447202
Publisher
Springer
Year
1986
Tongue
English
Weight
554 KB
Volume
35
Category
Article
ISSN
1573-9171

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โœ William J. Wheeler; Douglas D. O'Bannon; Joseph H. Kennedy; James A. Monn; Roger ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 177 KB

As part of a program aimed at the design of conformationally constrained analogs of glutamic acid, (+)-2-aminobicyclo[3.1.0]hexane-2,6-carboxylic acid (1), identified as a highly potent, selective, group II metabotropic glutamate receptor agonist has been synthesized and studied clinically. Heterocy