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Asymmetric total synthesis of reported structure of eudistomidin B, an indole alkaloid isolated from a marine tunicate

✍ Scribed by Takeshi Ito; Mariko Kitajima; Hiromitsu Takayama


Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
337 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis


Eudistomidin B, isolated from a marine tunicate, was originally assigned a tetrahydro-b-carboline structure with a 2-p-tolylethanamine residue. Asymmetric total synthesis of the reported structure of natural product, which features an intramolecular diastereoselective Pictet-Spengler cyclization, suggests that the reported structure of the natural product needs to be revised.


πŸ“œ SIMILAR VOLUMES


Eudistomidin G, a new Ξ²-carboline alkalo
✍ Yohei Takahashi; Haruaki Ishiyama; Takaaki Kubota; Jun’ichi Kobayashi πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 306 KB

A new b-carboline alkaloid, eudistomidin G (1), has been isolated from the Okinawan marine tunicate Eudistoma glaucus, and the structure was elucidated from spectroscopic data. Furthermore, the structure of eudistomidin B (2), which has been isolated from the same tunicate, was revised from 2a to 2b