Asymmetric total synthesis of reported structure of eudistomidin B, an indole alkaloid isolated from a marine tunicate
β Scribed by Takeshi Ito; Mariko Kitajima; Hiromitsu Takayama
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 337 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Eudistomidin B, isolated from a marine tunicate, was originally assigned a tetrahydro-b-carboline structure with a 2-p-tolylethanamine residue. Asymmetric total synthesis of the reported structure of natural product, which features an intramolecular diastereoselective Pictet-Spengler cyclization, suggests that the reported structure of the natural product needs to be revised.
π SIMILAR VOLUMES
A new b-carboline alkaloid, eudistomidin G (1), has been isolated from the Okinawan marine tunicate Eudistoma glaucus, and the structure was elucidated from spectroscopic data. Furthermore, the structure of eudistomidin B (2), which has been isolated from the same tunicate, was revised from 2a to 2b
## Abstract Isolation and structure elucidation of eudistomidin G (Ia) is described.