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Asymmetric total synthesis of natural pyrrolizidine alkaloid, (+)-alexine

✍ Scribed by Hidemi Yoda; Hideaki Katoh; Kunihiko Takabe

Book ID: 104210866
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 96 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01314-9

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✦ Synopsis

The total synthesis of the potent glycosidase inhibitor (+)-alexine with five contiguous stereogenic centres [(1R,2R,3R,7S,7aS)-3-hydroxymethyl-1,2,7-trihydroxypyrrolizidine alkaloid] is described featuring the efficient and stereodefined novel elaboration of the functionalized homochiral lactam derived from 2,3,5-tri-O-benzyl-b-D-arabinofuranose.

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