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Asymmetric total synthesis of (+)-cardiobutanolide via an iterative asymmetric dihydroxylation in PEG

✍ Scribed by S. Chandrasekhar; N. Kiranmai

Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 288 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.05.122

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✦ Synopsis

The stereoselective total synthesis of (+)-cardiobutanolide, a polyhydroxylated natural product, is achieved in high yield through Lu and Guo diene synthesis, Sharpless asymmetric dihydroxylation, and one-pot deprotection-lactonization. The utility of a recyclable reagent system in PEG for asymmetric dihydroxylation is demonstrated.

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