Asymmetric Total Synthesis of Batzelladine D
β Scribed by Cohen, Frederick; Overman, Larry E.; Ly Sakata, Sylvie K.
- Book ID
- 120485940
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 66 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1523-7060
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## Abstract Asymmetric total synthesis of batzelladine A (**1**) and batzelladine D (**2**) has been achieved. Our synthesis of batzelladines features 1) stereoselective construction of the cyclic guanidine system by means of successive 1,3βdipolar cycloaddition reaction and subsequent cyclization,
Scheme 1. Synthetic strategy toward batzelladines A and D. Boc = tertbutoxycarbonyl, Cbz = carbobenzyloxy, MPM = 4-methoxyphenylmethyl, TBS = tert-butyldimethylsilyl.