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Asymmetric Synthesis of α,α-Difluoro-β-amino Acid Derivatives from Enantiomerically Pure N-tert- Butylsulfinimines

✍ Scribed by Staas, Donnette D.; Savage, Kelly L.; Homnick, Carl F.; Tsou, Nancy N.; Ball, Richard G.


Book ID
120464689
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
91 KB
Volume
67
Category
Article
ISSN
0022-3263

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Convenient, large-scale asymmetric synth
✍ Vadim A Soloshonok; Hironari Ohkura; Alexander Sorochinsky; Natalia Voloshin; An 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 77 KB

The enantiopure p-toluenesulfinimines were found to be efficient as chiral imine equivalents in the high temperature Reformatsky-type additions with BrZnCF 2 COOEt affording an efficient approach to the enantiomerically pure a,a-difluoro-bamino acids. High chemical and stereochemical yields (drs>9:1