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Asymmetric Synthesis of α,α-Dibranched Amines by the Trimethylaluminum-Mediated 1,2-Addition of Organolithiums to tert -Butanesulfinyl Ketimines

✍ Scribed by Cogan, Derek A.; Ellman, Jonathan A.


Book ID
120224704
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
61 KB
Volume
121
Category
Article
ISSN
0002-7863

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Asymmetric synthesis of α,α-diaryl and α
✍ Anthony W Shaw; S.Jane deSolms 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 105 KB

Organometallic addition to tert-butanesufinyl ketimines derived from diaryl and aryl-heteroaryl ketones provided the corresponding a,a-diaryl and a-aryl-a-heteroaryl alkylamines in good yield with high diastereoselectivity. In many cases, imine facial selectivity is reversed on changing the organome