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Asymmetric synthesis of α-fluoro ketones using α-fluoro oxazolidinone carboximides

✍ Scribed by Franklin A. Davis; Parimala V.N. Kasu

Book ID
104259698
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
227 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The strategic introduction of fluorine into bioactive molecules is used to enhance biological activity, and study mechanisms of action. 1,2 In this context increasing attention is being directed towards the development of methodologies for the asymmetric synthesis of fluoro organic molecules where fluorine is attached to a stereogenic carbon. 3 This is in recognition of the importance of chirality in biologically and pharmacologically

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Nonracemic α-Fluoro Aldehydes: Asymmetric Synthesis of 4-Deoxy-4-fluoro-D-arabinopyranose. -The first enantioselective synthesis of epimerizable α-fluoro aldehyde (V) and its utility as chiral building block by the asymmetric synthesis of the title pyranose (XI) is described. The precursor for alde