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Asymmetric Synthesis of α-Amino Phosphonic Acids Employing Versatile Sulfinimines and Sulfonimines

✍ Scribed by Lefebvre, Isabelle M.; Evans, Slayton A.


Book ID
127222646
Publisher
Taylor and Francis Group
Year
1999
Tongue
English
Weight
171 KB
Volume
144
Category
Article
ISSN
1042-6507

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A versatile asymmetric synthesis of α-am
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A general protocol for the synthesis of a-amino-a-alkyl phosphonic acids in either enantiomeric form is described based on the alkylation of chiral bicyclic phosphonamides derived from (R,R)and (S,S)-1,2diaminocyclohexane. 2 CSu Br(CH&Br. 2. NaN,, DMF,140% Me Y Es& 70-75% (4) 4 h., 95%. (3) 2 Y= Cl