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Asymmetric Synthesis of α-Alkylated N -Sulfinyl Imidates as New Chiral Building Blocks

✍ Scribed by Colpaert, Filip; Mangelinckx, Sven; Verniest, Guido; De Kimpe, Norbert


Book ID
120057918
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
180 KB
Volume
74
Category
Article
ISSN
0022-3263

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Alkylation of 1,4-cyclohexanedione monoethylene acetal SAMP-hydrazone with various electrophiles (10 examples given) and subsequent cleavage of the hydrazones with saturated oxalic acid furnished highly enantiomerically enriched alpha-alkylated mono-protected 1,4-cyclohexanedione derivatives in high