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Asymmetric Synthesis of α-Alkyl-α-aminocarboxylic Acids by Alkylation of 1-chiral-Substituted 2-Imidazolin-5-ones

✍ Scribed by Prof. Dr. Ulrich Schöllkopf; Dr. Hans Heinrich Hausberg; Dr. Inga Hoppe; Dipl.-Chem. Marcos Segal; Dipl.-Chem. Udo Reiter


Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
346 KB
Volume
17
Category
Article
ISSN
0044-8249

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Enantioselective Synthesis of α-Methyl-α
✍ Prof. Dr. Ulrich Schöllkopf; Dr. Wolfgang Hartwig; Ulrich Groth 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 252 KB

The Z-configurated lactam (4a) formed as by-product proved to be stable under the reaction conditions, so a chromatographic separation was necessary. In an attempt to avoid this separation step we have studied the possibilities of E-2 isomerization. Whereas in the case of unsaturated C'5-unsubstitu