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Asymmetric synthesis of the lactone moiety of mevinic acid

✍ Scribed by Mark Lautens; Shihong Ma; Adrian Yee


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
195 KB
Volume
36
Category
Article
ISSN
0040-4039

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was .msolved. with Pseudomqnas jluoye~pase and one of the enanttomers was convetted mto a hey mtermedtate in the synthests of mevmr .

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## Abstract Starting from (__R__)‐__O__‐benzylglycidol and a sulfur‐stabilized allyl anion, a (3 + 3) synthesis of the Ξ±,β‐unsaturated (6__S__)‐δ‐lactone 7 is achieved. Subsequent diastereoselective addition of a phenyldimethylsilyl cuprate and unmasking of the latent hydroxy function provides the