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Asymmetric synthesis of the 6-cyanoindole derivatives as non-steroidal glucocorticoid receptor modulators using (+)- and (−)-tert-butyl 6-cyano-3-[3-ethoxy-1,1,1-trifluoro-2-hydroxy-3-oxopropan-2-yl]-1H-indole-1-carboxylate

✍ Scribed by Takaaki Sumiyoshi; Kengo Tojo; Daisuke Urabe; Masanori Tobe


Book ID
108284656
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
605 KB
Volume
22
Category
Article
ISSN
0957-4166

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PPh3-catalyzed knoevenagel condensation:
✍ Muvvala Venkatanarayana; Pramod Kumar Dubey 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 270 KB 👁 1 views

## Abstract Triphenylphosphine (TPP) has been utilized as a novel and efficient catalyst for the Knoevenagel condensation of indole‐3‐carboxaldehydes **1(a–e)**, 1‐methyl‐1H‐indole‐3‐carboxaldehydes **4(a–e)**, and 1‐ethyl‐1H‐indole‐3‐carboxaldehydes **6(a–e)** with the active methylene compound, t