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Asymmetric Synthesis of s yn - and a nti -1,3-Amino Alcohols

โœ Scribed by Kochi, Takuya; Tang, Tony P.; Ellman, Jonathan A.


Book ID
120038553
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
41 KB
Volume
124
Category
Article
ISSN
0002-7863

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Asymmetric synthesis of 1,2-amino alcoho
โœ So Won Youn; Jun Young Choi; Yong Hae Kim ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 112 KB ๐Ÿ‘ 2 views

Chiral hydrazones 1 reacted with aryl- or alkyl-lithiums at -78 degrees C in a short reaction time, within 10 min, to afford arylated or alkylated chiral hydrazines 3 with extremely high diastereoselectivity (up to >99% de) and high chemical yields. The hydrazines are readily converted to chiral ami