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Asymmetric Synthesis of (R)-(-)-Rhododendrol, the Aglycone of the Hepatoprotective Agent Rhododendrin.

✍ Scribed by Gowravaram Sabitha; B. Thirupathaiah; J. S. Yadav


Publisher
John Wiley and Sons
Year
2007
Weight
22 KB
Volume
38
Category
Article
ISSN
0931-7597

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A dimethylzinc/diphenylphosphinoylimine
✍ Sucharita Banerjee; Brad Smith; Shawn R. Hitchcock πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 127 KB πŸ‘ 1 views

## Abstract An asymmetric synthesis of the calcimimetic agent NPS R‐568 using a (1__R__,2__S__)‐__N__‐benzylephedrine‐promoted addition of dimethylzinc to a diphenylphosphinoylimine derived from 3‐methoxybenzaldehyde is described. The enantiomeric ratio of the key amine fragment was determined to b