Chiral organometallic reagents are of interest in stereoselective synthesis. This holds in particular for chiral aheterosubstituted organolithium and Grignard reagents. However, their reactions with electrophiles do not always take a stereochemically homogenous pathway. It is not clear In summary,
Asymmetric synthesis of (R)-?-phenylalkylamines via alkylation of chiral hydrazones by Grignard reagents
β Scribed by Takahashi, Hiroshi; Tomita, Kouichi; Otomasu, Hirotaka
- Book ID
- 115315583
- Publisher
- The Royal Society of Chemistry
- Year
- 1979
- Tongue
- English
- Weight
- 152 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0022-4936
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π SIMILAR VOLUMES
Oiastereoselective addition of organolithium reagents on hydrazones vicinal to chiral cyclic acetals provide chiral hydrazinoacetals from which optically active aminoacetals and aminoacids can be prepared. Recently the syntheses of optically active amines involving the addition of organometallic rea
The lithiation and alkylation of three aldehydes in the form of their a-phenethylimines has been shown to yield chiral a-alkvlaldehydes of 67-70% optical purity. We recently observed some unusual stereochemical preferences associated with lithiated ketimines (1) and aldimines (2). Both carbonyl deri