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Asymmetric synthesis of (R)-N-3-butyn-2-yl-N-hydroxyurea, a key intermediate for 5-lipoxygenase inhibitors

✍ Scribed by Teodozyj Kolasa; Andrew O. Stewart; Clint D.W. Brooks


Book ID
108036415
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
408 KB
Volume
7
Category
Article
ISSN
0957-4166

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Optically pure (R)-(l-naphthyhnethyl)succinic acid could be efficiently prepared by a combination of optical resolution and racemization of the undesired enantiomer or by catalytic asymmetric reduction of (1-naphthylmethylene)succinic acid over a rhodium (I)-chiral phosphine complex. Highly chemose