Asymmetric synthesis of (+)-trachyspic a
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Kenji Morokuma; Yuko Taira; Yumiko Uehara; Setsuya Shibahara; Keisuke Takahashi;
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Article
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2008
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Elsevier Science
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French
⚖ 189 KB
Aldol reaction of di-tert-butyl 4-(4-methoxybenzyloxy)-2-oxobutanoate with pent-4-enal using (S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(pyrrolidin-2-ylmethyl)thiourea hydrochloride as a catalyst, followed by Pinnick oxidation and tert-butyl esterification, gave (2S,3S)-di-tert-butyl 2-(2-(4-methoxybe