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Asymmetric synthesis of phenanthroindolizidine alkaloids with hydroxyl group at the C14 position and evaluation of their antitumor activities

โœ Scribed by Takashi Ikeda; Takashi Yaegashi; Takeshi Matsuzaki; Syusuke Hashimoto; Seigo Sawada


Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
209 KB
Volume
21
Category
Article
ISSN
0960-894X

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Chiral allyltitaniums having an amino substituent at the C-4 position are prepared from optically active allylic alcohol derivatives I and a Ti(O-i-Pr)4/2i-PrMgCl reagent, which, in turn, react with aldehydes regio-and stereoselectively to afford 3-amino-2-vinylalkanols in excellent yields.