✦ LIBER ✦

Asymmetric synthesis of N-protected chiral 1-aminoalkylphosphonic acids and synthesis of side chain–functionalized depsiphosphonopeptides

✍ Scribed by Han Liu; Shuzong Cai; Jiaxi Xu

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 100 KB
Volume: 12
Category: Article
ISSN: 1075-2617
DOI: 10.1002/psc.731

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✦ Synopsis

Optically active 1-aminoalkylphosphonic acid derivatives were synthesized in moderate yields and optical purities via Mannich-type reactions of benzyl carbamate, aldehydes, and optically pure chlorophosphites. Side chain-functionalized depsiphosphonopeptides were also prepared in satisfactory yields directly from one-pot reactions of benzyl carbamate, aldehydes, and diethyl (R,R)-2-chloro-1,3,2-dioxaphospholane-4,5-dicarboxylate.

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