Asymmetric synthesis of multicyclic spiro-1,3-indandiones via a cascade Michael/Michael reaction of curcumins and 2-arylidene-1,3-indandiones
β Scribed by Luo, Nian-hua; Sun, Xiang; Wei, Wen-tao; Zhang, Xue-jing; Yan, Ming
- Book ID
- 120194889
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 601 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0957-4166
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π SIMILAR VOLUMES
Asymmetric Michael addition of lithiated SAMP hydrazones (S)-2 to a variety of alkenylphosphonates (E)-3 followed by oxidative cleavage of the 1,4-adducts 4 afforded 2,3-disubstituted 4-oxophosphonates 5 with good to very good yields (58-80%), low to moderate diastereomeric (de 6-74%) and excellent
## Abstract Starting from the easily accesible chiral aldehyde 2, we obtained enantiomerically pure (__Z__)β and (__E__)βΞ±,βchloroβΞ±,Ξ²βunsaturated esters 4c in good yields by olefination reactions. (__Z__)βand (__E__)β4c were allowed to react with the kinetically controlled generated lithium dienol