Quinine and quinidine were synthesized by a highly enantio-and stereoselective approach starting from a proline-catalyzed asymmetric cycloaldolization of benzyl bis(2-formylethyl)carbamate which gave a 70:30 mixture of (3R,4R)-N-Cbz-3-hydroxymethyl-4-hydroxypiperidine (96% ee) and its 4S-epimer (92%
✦ LIBER ✦
Asymmetric Synthesis of (+)-Mequitazine from Quinine
✍ Scribed by Leroux, Sébastien; Larquetoux, Laurent; Nicolas, Marc; Doris, Eric
- Book ID
- 126989158
- Publisher
- American Chemical Society
- Year
- 2011
- Tongue
- English
- Weight
- 683 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1523-7060
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The first in a new series, this book provides chemists an effective, much-needed way to stay abreast of recent developments in organic synthesis. The 103 articles review the leading synthetic procedures developed from 2003 - 2005, discussing their significance and their applications. More than 100 r