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Asymmetric Synthesis of Diazepino-β-lactams by [2 + 2] Cycloaddition of an ‘Evans-Sjogven’ Ketene with 1H-1,2-Diazepines

✍ Scribed by Marc Muller; Daniel Bur; Théophile Tschamber; Jacques Streith


Publisher
John Wiley and Sons
Year
1991
Tongue
German
Weight
458 KB
Volume
74
Category
Article
ISSN
0018-019X

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[2+2] Cycloaddition Reactions of Imines
✍ Giuseppe Cremonesi; Piero Dalla Croce; Concetta La Rosa 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 German ⚖ 190 KB

## Abstract Unsymmetric cyclic ketenes were generated from __N__‐acyl‐1,3‐thiazolidine‐2‐carboxylic acids **1a**–**c** by means of __Mukaiyama__'s reagent, and then reacted with imines **2a**–**c** to the new, isomeric spiro‐__β__‐lactams **3** and **4** __via__ [2+2] cycloaddition (__Staudinger__