Asymmetric Synthesis of cis -2,5-Disubstituted Pyrrolidine, the Core Scaffold of β 3 -AR Agonists
✍ Scribed by Xu, Feng; Chung, John Y. L.; Moore, Jeffery C.; Liu, Zhuqing; Yoshikawa, Naoki; Hoerrner, R. Scott; Lee, Jaemoon; Royzen, Maksim; Cleator, Ed; Gibson, Andrew G.; Dunn, Robert; Maloney, Kevin M.; Alam, Mahbub; Goodyear, Adrian; Lynch, Joseph; Yasuda, Nobuyashi; Devine, Paul N.
- Book ID
- 120013354
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 523 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1523-7060
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Selective One-Step Synthesis of Enantiopure cis-2,5-Disubstituted Pyrrolidines or cis-3,6-Disubstituted Piperidines from the (2R,2'R)-(1,2-Ethanediyl)bis-aziridine. -Chromatographic purification of the optically active bis-aziridine (I) results in a 5-exo-tet aminocyclization to the cis-2,5-disubst