Asymmetric synthesis of chiral synthons bearing alkynyl group via organoaluminum-promoted pinacol-type rearrangement

✍ Scribed by Keisuke Suzuki; Takeshi Ohkuma; Mayumi Miyazawa; Gen-ichi Tsuchihashi

• Book ID: 104218136
• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 220 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)84022-8

✦ Synopsis

A method is described for the synthesis of chiral alkynyl ketones and alkynols via trimethylaluminum-promoted pinacol-type rearrangement where alkynyl groups behave as "the staying group", followed by stereoselective reduction leading to the latter.