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Asymmetric synthesis of [C-1-3H]-labelled (+)-trans [1R,3R]-chrysanthemic acid

✍ Scribed by Gerald Pattenden; Richard Storer

Publisher: John Wiley and Sons
Year: 1976
Tongue: French
Weight: 212 KB
Volume: 12
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580120411

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✦ Synopsis

Abstract

A facile asymmetric synthesis of [C‐1‐^3^H]‐labelled (+)‐trans[1R,3R]‐chrysanthemic acid, required for biosynthetic studies is described. The tritium labelled acid is prepared from the corresponding (−)‐cis[1S,3R]‐ester by selective epimerisation of the C‐1 centre in the latter, in the presence of tritiated water.

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