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Asymmetric Synthesis of 4′-Methyl-2′,3′-dideoxynucleosides

✍ Scribed by Luzzio, Frederick A.; Mayorov, Alexander V.; Menes, Michael E.; Champion, William L.


Book ID
120459502
Publisher
Taylor and Francis Group
Year
1999
Tongue
English
Weight
482 KB
Volume
18
Category
Article
ISSN
0732-8311

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Synthesis of 6-dimethylaminopurine 2′,3′
✍ Motawia, Mohammed S. ;El-Torgoman, Abdel Moneim ;Pedersen, Erik B. 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 547 KB

## Abstract The trimethylsilyated 6‐dimethylaminopurine 1 was coupled with the 2′,3′‐dideoxyribose derivatives 2a, b and 7 by using trimethylsilyl triflate as catalyst to yield the corresponding nucleosides 3a, b, 4a, b and 8, which were appropriately deprotected to give the desired nucleosides 5a,