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Asymmetric Synthesis of (2R,3R,4R)-3-Hydroxy-4-methylproline via Chromium(II) Chloride-mediated Coupling Reactions of (S)-Garner Aldehyde with Crotyl Bromide

✍ Scribed by Aoyagi, Yutaka; Inaba, Haruko; Hiraiwa, Yukiko; Yoshida, Satoshi; Tamura, Mina; Kuroda, Asako; Ogawa, Aki; Ohta, Akihiro; Takeya, Koichi


Book ID
124078513
Publisher
Japan Institute of Heterocyclic Chemistry
Year
2005
Tongue
English
Weight
184 KB
Volume
65
Category
Article
ISSN
0385-5414

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Electroorganic synthesis, 57. Synthesis
✍ Weiguny, Jens ;Schäfer, Hans J. 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 821 KB

## Abstract The α‐silyl‐substituted carboxylic acids 4 and 10 were prepared and with other coacids subjected to a mixed Kolbe electrolysis with β‐cyclopentenyloxypropanoate 1. The stereochemical course of this cyclization reaction was determined on the basis of the 4‐methyl‐substituted product 23 b