Asymmetric Synthesis of 2-Substituted Piperidines. Synthesis of the Alkaloids (−)-Coniine and (+)-Pseudoconhydrine
✍ Scribed by Moody, Christopher J.; Lightfoot, Andrew P.; Gallagher, Peter T.
- Book ID
- 127119947
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 130 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0022-3263
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AbstractÐThis paper describes a new general approach towards functionalized piperidine alkaloids, based on the stereo-and regioselective palladium(0)-catalyzed nucleophilic ring-opening of vinyl epoxides by nitrogen nucleophiles. The latter reaction provides access to stereo-de®ned anti and syn amin
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