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Asymmetric Synthesis of 2-Substituted Oxetan-3-ones via Metalated SAMP/RAMP Hydrazones

✍ Scribed by Geden, Joanna V.; Beasley, Benjamin O.; Clarkson, Guy J.; Shipman, Michael


Book ID
121694486
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
439 KB
Volume
78
Category
Article
ISSN
0022-3263

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📜 SIMILAR VOLUMES


Asymmetric michael additions via SAMP/RA
✍ Enders, Dieter ;Wahl, Heiner ;Papadopoulos, Kyriakos 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 979 KB

## Abstract Asymmetric Michael addition of lithiated methyl ketone SAMP hydrazones (S)‐3 to a variety of alkenylphosphonates (E)‐2 followed by oxidative cleavage of the 1,4‐adducts (__S,S__)‐4 by ozonolysis afforded 2‐substituted 4‐oxophosphonates (__S__)‐5 in usually moderate to very good overall

Enantioselective synthesis of α-sulfenyl
✍ Dieter Enders; Thomas Schäfer; Wolfgang Mies 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 776 KB

Asymmetric ot-sulfenylation of lithiated SAMP/RAMP hydrazoncs (3")-2 with disulfides afforded tz-thiolated hydrazones (S,R)-3 in good yields (48-87%) and high diastcreomeric excesses (91-96%). Subsequent oxidative cleavage or acidic hydrolysis of the hydrazones furnished a-thiolated ketones (R)-4a.d