Asymmetric synthesis of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740)
✍ Scribed by Carmen Domínguez; Jesús Ezquerra; Lourdes Prieto; Modesta Espada; Carmen Pedregal
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 257 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
As part of a program aimed at the design of conformationally constrained analogs of glutamic acid, (+)-2-aminobicyclo[3.1.0]hexane-2,6-carboxylic acid (1), identified as a highly potent, selective, group II metabotropic glutamate receptor agonist has been synthesized and studied clinically. Heterocy
## Abstract A process for double deuterium labeling of an alcohol was developed. The process was utilized in the subsequent tritium labeling of a secondary alcohol with high specific activity (24 Ci/mmol) by reduction of the corresponding ketone using sodium borotritide. The starting ketone was fir