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Asymmetric Synthesis and Structure-Activity Relationship of the Four Stereoisomers of the Antibiotic Amidinomycin Part 2: Microbiological Testing

✍ Scribed by Sun-Young Sung; Manfred Kist; August W. Frahm

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
291 KB
Volume
330
Category
Article
ISSN
0365-6233

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✦ Synopsis

The stereoisomers of amidinomycin 7 and their intermediates 1-6, which are produced from homochiral 3-oxocyclopentanecarboxylic acids by asymmetric synthesis, are tested for their antimicrobial effects by agar diffusion test and by Bouillon serial dilution assay. Their antibiotic activities against Bacillus subtilis, Staphylococcus aureus, and Micrococcus Iuteus, respectively, are reported. Structure-activity relationships depend on the type and combination of functional groups, on only the relative stereochemistry as well as on the grade of lipophilia of the tested compounds.

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