Asymmetric synthesis and cytotoxic activity of isomeric phytosphingosine derivatives
✍ Scribed by Rives, Arnaud; Baudoin-Dehoux, Cécile; Saffon, Nathalie; Andrieu-Abadie, Nathalie; Génisson, Yves
- Book ID
- 118061694
- Publisher
- Royal Society of Chemistry
- Year
- 2011
- Tongue
- English
- Weight
- 279 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1477-0520
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📜 SIMILAR VOLUMES
## Abstract Reaction of the lithium acetylide prepared from bromooctene 2 with 2,4‐__O__‐benzylidene‐D‐threose (1) yielded the epimeric dodec‐5‐ynetetrol derivatives 3a, b. Reaction of the Grignard reagent of bromooctene 2 with 1 gave (__E__,Z)‐dodec‐5‐ene‐tetrol derivatives (__E__,Z)‐12a,b. From t
Tlic first asymmetric synthesis of a phytosphingosine, (ZS,38,4R)-2-amino-1.3.4-hexadecanetriol (Z), was accomplishd by kinetic resolution and asymmetric cpoxidation. The absolute stereochcmislry of the phytosphingosine from starfishes (Amithasier plniici iind Astcrinrr prciin~jkrrr) was cstnblishcd